Biography
Stanley Tamaki has worked 20 year on human tissue specific stem cells, including, hematopoietic stem cells, neural stem cells, liver engrafting cells, pancreatic islet cells and currently skeletal muscle satellite cells. His expertise, is developing processes for the isolation and identification of cell surface markers for the prospective purification of various tissue stem cells. He has developed several murine disease models that have been used to demonstrate the successful engraftment and in vivo efficacy of the various purified human stem cells. He has also developed a panel of human specific antibodies, now commercially available, used to detect donor cell engraftment
Education
Ph.D. 1990, Plant Pathology, University of California, Riverside
B.S. 1980, Genetics, University of California, Berkeley
Morris, T.J., J.A. Dodds, B. Hillman, R.L. Jordan, S.A. Lommel and S.J. Tamaki. 1983. Viral specific ds RNA: diagnostic value for plant virus disease identification. Plant Mol. Biol. Rep. 1:27-30.
Dean, C., P. van den Elzen, S. Tamaki, P. Dunsmuir, and J. Bedbrook. 1985. Linkage and homology analysis divides the eight genes for the small subunit of petunia ribulose 1,5-bisphosphate carboxylase into three gene families. Proc. Natl. Acad. Sci. 82:4964-68.
Dean, C., P. van den Elzen, S. Tamaki, P. Dunsmuir, and J. Bedbrook. 1985. Differential expression of the eight genes of the petunia ribulose bisphosphate carboxylase small subunit multi-gene family. EMBO J. 4: 3055-61.
Dean, C., P. van den Elzen, S. Tamaki, P. Dunsmuir, and J. Bedbrook. 1985. Molecular characterization of the rbcS multi-gene family of Petunia (Mitchell). MGG 206: 465-474.
Dean, C., P., S. Tamaki, P. Dunsmuir, M. Favreau, C. Katayama, H. Dooner and J. Bedbrook. 1987. MRNA transcripts of several plant genes are polyadenylated at multiple sites in vivo. Nuc. Acid Res. 14: 2229-40.
Keen, N.T., S. Tamaki. 1985. Pectic enzymes: a role in plant/pathogen specificity. In Plant Cell/Cell Interactions. Eds. Sussex, I., A. Ellingboe, M. Crouch, R. Malmberg. Current Commun. In Molec. Biol. Coldspring Harbor. Pp. 137-43.
Keen, N.T., S. Tamaki. 1986. Structure of two pectate lyase genes from Erwinia chrysanthemi EC16 and their high-level expression in Escherichia coli. J. Bacteriol. 168: 595-606.
Dean, C., M. Favreau, S. Tamaki, J. Jones, P. Dunsmuir, and J. Bedbrook 1987. Expression of petunia rbcS gene fusions in transformed tobacco plants. In Plant Gene Systems and their Biology. Eds. Key J. and L. McIntosh. UCLA Symposium 62:298-99.
Tamaki, S.J., S. Gold, M. Roberson, S. Manulis and N.T. Keen. 1988. Structure and organization of the pel genes from Erwinia chysanthemi. J. Bacteriol 170: 3468-3478.
Tamaki, S.J., D. Dahlbeck, B. Staskawicz and N.T. Keen. 1988. Characterization and expression of two avriulence genes cloned from Pseudomonas syringae pv. glycinea. J. Bacteriol. 170: 4846-4854.
Dean, C., M. Favreau, S. Tamaki, D. Bond-Nutter, P. Dunsmuir, and J. Bedbrook. 1988. Expression of tandem gene fusions in transgenic plants. Nuc. Acid Res. 16: 7601-17.
Keen, N.T., S. Tamaki, D. Kobayashi, and D. Trollinger. 1988. Improved plasmids for cloning bacterial DNA. Gene 70: 191-197.
Keen, N.T., D. Kobayashi, S. Tamaki, , H. Thordal- Christensen, I. Misaghi, S. Hao, D. Trollinger, D. Dahlbeck and B. Staskawicz. 1988. Characterization of avirulence genes from Pseudomonas syringae pathovars and races. In Molec. Plant-Microbe Interactions. Ed. By D. Verma and R. Palacios. APS Press, St. Paul, Minn.
Kobayashi, D.K., S.J. Tamaki, and N.T. Keen. 1988. Cloned avirulence genes from the tomato pathogen P. syringae pv. tomato conferring cultivar specificity on the non-host soybean. PNAS 86: 157-161.
Kobayashi, D.K., S.J. Tamaki, and N.T. Keen. 1990. Molecular characterization of avirulence gene D from Pseudomonas syringae pv. tomato. Molecular Plant –Microbe Interactions, 3: 94-102.
Kobayashi, D.K., S.J. Tamaki, D.J. Trollinger, S. Gold, and N.T. Keen. 1990. A gene from Pseudomonas syringae pv.glycinea with homology to avirulence gene D from P.s. pv. tomato but devoid of the avirulence phenotype. Molecular Plant –Microbe Interactions, 3: 103-11.
Keen, N.T., S. Tamaki, D. Kobayashi, D. Gerhold, M. Stayton, H. Shen, S. Gold, J. Lorang, H. Thordal- Christensen, D. Dahlbeck and B. Staskawicz. Bacteria expressing avirulence gene D produce a specific elicitor of the soybean hypersensitive reaction. Molecular Plant –Microbe Interactions, 3: 87-93.
Tamaki, S.J., D. Kobayashi, N.T. Keen. 1991. Sequence domains required for the activity of avirulence genes avrB and avrC from Pseudomonas syringae pv. glycinea. J. Bacteriol. 173: 301-7.
Tamaki, S., and W.T. Frankenberger Jr. 1992. Environmental biochemistry of arsenic. Reviews of Environmental Contamination and Toxicology. 124:79-110.
Shen, H., S.E. Gold, S.J. Tamaki, and N.T. Keen. 1992. Construction of a Tn-7 lux system for gene expression studies in gram-negative bacteria. Gene 122:27-34.
Schlaifer, D., K. Meyer, C. Muller, M. Attal, M.T. Smith, S. Tamaki, J. Pris J.P. Jaffrexou, G. Laurent and C.E. Myers. 1994. Antisense inhibition of myeloperoxidase increases the sensitivity of the HL-60 cell line to vincristine. Leukemia 8: 289-291.
Schaad, N.W., Cheong, S.S., S. Tamaki, Hatzioukas, E., and Panopolous N. 1995. A combined biological and enzymatic amplification (BIO-PCR) technique to detect Pseudomonas syringae pv. phaseolicola in bean seed extracts. Phytopathology. 85; 243-248.
Bowers E., Tamaki S., Coward A., Kaneshima H., Chao C.C. 2000. Differing functional recovery of donor-derived immune cells after purified haploidentical and fully mismatched hematopoietic stem cell transplantation in mice. Exp Hematol.28; 1481-9.
Berkowitz R., Ilves H., Lin W.Y., Eckert K., Coward A., Tamaki S., Veres G., Plavec I. 2001. Construction and molecular analysis of gene transfer systems derived from bovine immunodeficiency virus. J Virol. Apr; 75:3371-82.
Tamaki S., Eckert K., He D., Sutton R., Doshe M., Jain G., Tushinski R., Reitsma M., Harris B., Tsukamoto A., Gage F., Weissman I., Uchida N. 2002. Engraftment of sorted/expanded human central nervous system stem cells from fetal brain. J Neurosci Res.69; 976-86.
Cummings, B.J., Uchida, N., Tamaki, S.J., Salazar, D.L., Hooshmand, M., Summers, R., Gage, F.H. and Anderson, A.J. 2005. Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice, Proc Natl Acad Sci U S A.102;14069-74.
Cummings, B.J., Uchida, N., Tamaki, S.J., and Anderson, A.J. Human neural stem cell differentiation following transplantation into spinal cord injured mice: association with recovery of locomotor function Neurol Res. 2006 Jul;28(5):474-81.
Xiong A., Austin T.W., Lagasse E., Uchida N., Tamaki S., Bordier B.B., Weissman I.L., Glenn J.S., Millan M.T. Isolation of Human Fetal Liver Progenitors and Their Enhanced Proliferation by Three-Dimensional Coculture with Endothelial Cells. Tissue Eng Part A. 2008 Jun;14(6):995-1006.
Tamaki S.J., Jacobs Y., Doshe M., Capela A., Cooper J.D., Reitsma M., He D., Tushinski R., Belichenko P.V., Salehi A., Mobley W., Gage F.H., Huhn S., Tsukamoto A.S., Weissman I.L., Uchida N. Neuroprotection of host cells by human central nervous system stem cells in a mouse model of infantile neuronal ceroid lipofuscinosis. Cell Stem Cell. 2009 Sep 4; 5(3):310-9.
Hooshmand MJ, Sontag CJ, Uchida N, Tamaki S, Anderson AJ, Cummings BJ. Analysis of host-mediated repair mechanisms after human CNS-stem cell transplantation for spinal cord inury: correlation of engraftment with recovery. PLoS One. 2009 Jun 11;4(6):e5871
Uchida N, Chen K, Dohse M, Hansen KD, Dean J, Buser JR, Riddle A, Beardsley DJ, Wan Y, Gong X, Nguyen T, Cummings BJ, Anderson AJ, Tamaki SJ, Tsukamoto A, Weissman IL, Matsumoto SG, Sherman LS, Kroenke CD, Back SA Human neural stem cells induce functional myelination in mice with severe dysmyelination. Sci Transl Med. 2012 Oct 10;4(155):155ra136 4(155)
Stanley Tamaki, Christopher Nye, Euan Slorach, David Scharp, Helen M. Blau, Phyllis E. Whiteley, and Jason H. Pomerantz. Simultaneous Silencing of multiple RB and p53 pathway members induces cell cycle reentry in intact human pancreatic Islet Cells BMC Biotechnol. 2014 Oct 11;14:86. doi: 10.1186/1472-6750-14-86
Research Interests
Human tissue stem cell specific isolation
Human stem cell transplantation