University of California San Francisco

Emilie Barruet Photo 20120924 Cropped 0
Emilie Barruet, PhD

Supervised Postdoctoral Fellowship, 2019 - 2023
Associate Specialist, Surgery
Project Scientists, Cedars-Sinai

Education

Institution Degree Dept or School End Date
Mediterranean University of Medicine Ph.D Human Pathology & Genomics 2010
University of Burgundy M.S. Biochemistry, Cellular & Molecular Biology 2006
Bucknell University B.S. Biology 2005

Research Interests

  • Stem cell biology
  • Regenerative medicine
  • Induced pluripotent stem cell
  • Musculoskeletal biology

Publications

MOST RECENT PUBLICATIONS FROM A TOTAL OF 29
  1. Patterning and folding of intestinal villi by active mesenchymal dewetting.
    Huycke TR, Häkkinen TJ, Miyazaki H, Srivastava V, Barruet E, McGinnis CS, Kalantari A, Cornwall-Scoones J, Vaka D, Zhu Q, Jo H, Oria R, Weaver VM, DeGrado WF, Thomson M, Garikipati K, Boffelli D, Klein OD, Gartner ZJ| | PubMed
  2. Patterning and folding of intestinal villi by active mesenchymal dewetting.
    Huycke TR, Miyazaki H, Häkkinen TJ, Srivastava V, Barruet E, McGinnis CS, Kalantari A, Cornwall-Scoones J, Vaka D, Zhu Q, Jo H, DeGrado WF, Thomson M, Garikipati K, Boffelli D, Klein OD, Gartner ZJ| | PubMed
  3. Loss of transcriptional heterogeneity in aged human muscle stem cells.
    Barruet E, Striedinger K, Marangoni P, Pomerantz JH| | PubMed
  4. Heterogeneous levels of delta-like 4 within a multinucleated niche cell maintains muscle stem cell diversity.
    Eliazer S, Sun X, Barruet E, Brack AS| | PubMed
  5. ACVR1-activating mutation causes neuropathic pain and sensory neuron hyperexcitability in humans.
    Yu X, Ton AN, Niu Z, Morales BM, Chen J, Braz J, Lai MH, Barruet E, Liu H, Cheung K, Ali S, Chan T, Bigay K, Ho J, Nikolli I, Hansberry S, Wentworth K, Kriegstein A, Basbaum A, Hsiao EC| | PubMed
  6. Corrigendum to "ACVR1R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophages" [Bone. 153 2021 Dec; 116129. doi:10.1016/j.bone.2021.116129. Epub 2021 Jul 24. PMID: 34311122].
    Matsuo K, Lepinski A, Chavez RD, Barruet E, Pereira A, Moody TA, Ton AN, Sharma A, Hellman J, Tomoda K, Nakamura MC, Hsiao EC| | PubMed
  7. Modeling the ACVR1R206H mutation in human skeletal muscle stem cells.
    Barruet E, Garcia SM, Wu J, Morales BM, Tamaki S, Moody T, Pomerantz JH, Hsiao EC| | PubMed
  8. ACVR1R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophages.
    Matsuo K, Lepinski A, Chavez RD, Barruet E, Pereira A, Moody TA, Ton AN, Sharma A, Hellman J, Tomoda K, Nakamura MC, Hsiao EC| | PubMed
  9. Purification and preservation of satellite cells from human skeletal muscle.
    Striedinger K, Barruet E, Pomerantz JH| | PubMed
  10. Satellite cell activation and retention of muscle regenerative potential after long-term denervation.
    Wong A, Garcia SM, Tamaki S, Striedinger K, Barruet E, Hansen SL, Young DM, Pomerantz JH| | PubMed
29
View all 29 Publications
MOST RECENT PUBLICATIONS FROM A TOTAL OF 29
  1. Patterning and folding of intestinal villi by active mesenchymal dewetting.
    Huycke TR, Häkkinen TJ, Miyazaki H, Srivastava V, Barruet E, McGinnis CS, Kalantari A, Cornwall-Scoones J, Vaka D, Zhu Q, Jo H, Oria R, Weaver VM, DeGrado WF, Thomson M, Garikipati K, Boffelli D, Klein OD, Gartner ZJ| | PubMed
  2. Patterning and folding of intestinal villi by active mesenchymal dewetting.
    Huycke TR, Miyazaki H, Häkkinen TJ, Srivastava V, Barruet E, McGinnis CS, Kalantari A, Cornwall-Scoones J, Vaka D, Zhu Q, Jo H, DeGrado WF, Thomson M, Garikipati K, Boffelli D, Klein OD, Gartner ZJ| | PubMed
  3. Loss of transcriptional heterogeneity in aged human muscle stem cells.
    Barruet E, Striedinger K, Marangoni P, Pomerantz JH| | PubMed
  4. Heterogeneous levels of delta-like 4 within a multinucleated niche cell maintains muscle stem cell diversity.
    Eliazer S, Sun X, Barruet E, Brack AS| | PubMed
  5. ACVR1-activating mutation causes neuropathic pain and sensory neuron hyperexcitability in humans.
    Yu X, Ton AN, Niu Z, Morales BM, Chen J, Braz J, Lai MH, Barruet E, Liu H, Cheung K, Ali S, Chan T, Bigay K, Ho J, Nikolli I, Hansberry S, Wentworth K, Kriegstein A, Basbaum A, Hsiao EC| | PubMed
  6. Corrigendum to "ACVR1R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophages" [Bone. 153 2021 Dec; 116129. doi:10.1016/j.bone.2021.116129. Epub 2021 Jul 24. PMID: 34311122].
    Matsuo K, Lepinski A, Chavez RD, Barruet E, Pereira A, Moody TA, Ton AN, Sharma A, Hellman J, Tomoda K, Nakamura MC, Hsiao EC| | PubMed
  7. Modeling the ACVR1R206H mutation in human skeletal muscle stem cells.
    Barruet E, Garcia SM, Wu J, Morales BM, Tamaki S, Moody T, Pomerantz JH, Hsiao EC| | PubMed
  8. ACVR1R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophages.
    Matsuo K, Lepinski A, Chavez RD, Barruet E, Pereira A, Moody TA, Ton AN, Sharma A, Hellman J, Tomoda K, Nakamura MC, Hsiao EC| | PubMed
  9. Purification and preservation of satellite cells from human skeletal muscle.
    Striedinger K, Barruet E, Pomerantz JH| | PubMed
  10. Satellite cell activation and retention of muscle regenerative potential after long-term denervation.
    Wong A, Garcia SM, Tamaki S, Striedinger K, Barruet E, Hansen SL, Young DM, Pomerantz JH| | PubMed
  11. MON-710 ACVR1 Activation in Primary and iPS-Derived Human Skeletal Muscle Stem Cells Impairs Myogenic Transcriptional Signature and Function.
    Emilie Barruet, Steven Garcia, Stanley Tamaki, Blanca M Morales, Jake Wu, Tania Moody, Jason H Pomerantz, Edward Chiaming Hsiao| | UCSF Research Profile
  12. Functionally heterogeneous human satellite cells identified by single cell RNA sequencing.
    Barruet E, Garcia SM, Striedinger K, Wu J, Lee S, Byrnes L, Wong A, Xuefeng S, Tamaki S, Brack AS, Pomerantz JH| | PubMed
  13. Inflammation in Fibrodysplasia Ossificans Progressiva and Other Forms of Heterotopic Ossification.
    Matsuo K, Chavez RD, Barruet E, Hsiao EC| | PubMed
  14. Effect of donor variation on osteogenesis and vasculogenesis in hydrogel cocultures.
    Pennings I, van Dijk LA, van Huuksloot J, Fledderus JO, Schepers K, Braat AK, Hsiao EC, Barruet E, Morales BM, Verhaar MC, Rosenberg AJWP, Gawlitta D| | PubMed
  15. NF-κB/MAPK activation underlies ACVR1-mediated inflammation in human heterotopic ossification.
    Barruet E, Morales BM, Cain CJ, Ton AN, Wentworth KL, Chan TV, Moody TA, Haks MC, Ottenhoff TH, Hellman J, Nakamura MC, Hsiao EC| | PubMed
  16. Application of human induced pluripotent stem cells to model fibrodysplasia ossificans progressiva.
    Barruet E, Hsiao EC| | PubMed
  17. The ACVR1 R206H mutation found in fibrodysplasia ossificans progressiva increases human induced pluripotent stem cell-derived endothelial cell formation and collagen production through BMP-mediated SMAD1/5/8 signaling.
    Barruet E, Morales BM, Lwin W, White MP, Theodoris CV, Kim H, Urrutia A, Wong SA, Srivastava D, Hsiao EC| | PubMed
  18. Loss of Iroquois homeobox transcription factors 3 and 5 in osteoblasts disrupts cranial mineralization.
    Cain CJ, Gaborit N, Lwin W, Barruet E, Ho S, Bonnard C, Hamamy H, Shboul M, Reversade B, Kayserili H, Bruneau BG, Hsiao EC| | PubMed
  19. Using Human Induced Pluripotent Stem Cells to Model Skeletal Diseases.
    Barruet E, Hsiao EC| | PubMed
  20. Efficient and cost-effective generation of mature neurons from human induced pluripotent stem cells.
    Badja C, Maleeva G, El-Yazidi C, Barruet E, Lasserre M, Tropel P, Binetruy B, Bregestovski P, Magdinier F| | PubMed
  21. Induced pluripotent stem cells from patients with human fibrodysplasia ossificans progressiva show increased mineralization and cartilage formation.
    Matsumoto Y, Hayashi Y, Schlieve CR, Ikeya M, Kim H, Nguyen TD, Sami S, Baba S, Barruet E, Nasu A, Asaka I, Otsuka T, Yamanaka S, Conklin BR, Toguchida J, Hsiao EC| | PubMed
  22. A p38MAPK-p53 cascade regulates mesodermal differentiation and neurogenesis of embryonic stem cells.
    Hadjal Y, Hadadeh O, Yazidi CE, Barruet E, Binétruy B| | PubMed
  23. The plasminogen activation system modulates differently adipogenesis and myogenesis of embryonic stem cells.
    Hadadeh O, Barruet E, Peiretti F, Verdier M, Bernot D, Hadjal Y, Yazidi CE, Robaglia-Schlupp A, De Paula AM, Nègre D, Iacovino M, Kyba M, Alessi MC, Binétruy B| | PubMed
  24. p38 mitogen activated protein kinase controls two successive-steps during the early mesodermal commitment of embryonic stem cells.
    Barruet E, Hadadeh O, Peiretti F, Renault VM, Hadjal Y, Bernot D, Tournaire R, Negre D, Juhan-Vague I, Alessi MC, Binétruy B| | PubMed
  25. PO29 La down-régulation de TIMP-3 est nécessaire à la différenciation adipocytaire.
    D. Bernot, E. Barruet, M. Poggi, B. Bonardo, M.C. Alessi, F. Peiretti| | UCSF Research Profile
  26. Down-regulation of tissue inhibitor of metalloproteinase-3 (TIMP-3) expression is necessary for adipocyte differentiation.
    Bernot D, Barruet E, Poggi M, Bonardo B, Alessi MC, Peiretti F| | PubMed
  27. B008 Régulation du « système ADAM17 » au cours de la différenciation adipocytaire.
    D. Bernot, E. Barruet, M. Poggi, G. Nalbone, M.-C. Alessi, F. Peiretti| | UCSF Research Profile
  28. D027 Role de la voie de transduction P38MAPK (mitogen-activated protein kinase) dans les differenciations endotheliales et myogeniques des cellules souches embryonnaires.
    E. Barruet, F. Peiretti, O. Hadadeh, I. Juhan-vague, M.-C. Alessi, B. Binetruy| | UCSF Research Profile
  29. D028 L’expression des gènes PAI-1, tPA et uPA est fortement régulée pendant la différenciation des cellules souches embryonnaires en myocytes et adipocytes.
    O. Hadadeh, E. Barruet, F. Peiretti, M. Verdier, I. Juhan-vague, M.-C. Alessi, B. Binetruy| | UCSF Research Profile